Late results of combined iodine-125 and external beam radiotherapy in carcinoma of prostate

A total of 96 patients were treated for localized carcinoma of the prostate using combined Iodine-125 (125I) implantation and external beam radiotherapy. The implant was tailored to deliver 10,000 rad to the periphery of the prostate. A significant incidence of serious late rectal complications was...

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Bibliographic Details
Published in:	Urology (Ridgewood, N.J.) Vol. 36; no. 1; p. 27
Main Authors:	Patel, J, Worthen, R, Abadir, R, Weaver, D J, Weinstein, S, Ross, Jr, G
Format:	Journal Article
Language:	English
Published:	United States 01-07-1990
Subjects:	Fistula - etiology Follow-Up Studies Humans Iodine Radioisotopes - therapeutic use Lymphatic Metastasis Male Neoplasm Staging Proctitis - etiology Prostatic Diseases - etiology Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Radiation Injuries Radiotherapy - methods Rectal Fistula - etiology Recurrence Survival Rate Urinary Incontinence - etiology
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Summary:	A total of 96 patients were treated for localized carcinoma of the prostate using combined Iodine-125 (125I) implantation and external beam radiotherapy. The implant was tailored to deliver 10,000 rad to the periphery of the prostate. A significant incidence of serious late rectal complications was observed. Positive pelvic nodes were found in 28 percent of the patients. Disease-free survival at seven years was 76 percent for those with negative nodes and 46 percent for patients with positive nodes.
ISSN:	0090-4295
DOI:	10.1016/0090-4295(90)80307-9