桂枝의 collagen 유발 관절염에 대한 소염 효과

• Published in: 동의생리병리학회지 Vol. 22; no. 3; pp. 542 - 547
• Main Authors: 김성준(Sung Joon Kim), 박성민(Sung Min Park), 강희(Hee Kang), 심범상(Bum Sang Shim), 김성훈(Sung Hoon Kim), 최승훈(Seung Hoon Choi), 안규석(Kyoo Seok Ahn)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01-06-2008
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

In order to examine anti-inflammatory effect of Cinnamomi Ramulus (CR) alcohol extract on rheumatoid arthritis, the present study investigated the viability and TNF-α production in Raw264.7 cells treated with CR and collagen induced arthritis in DBA/1J mice which were orally administered with CR prior to immunization. The results are as follows: CR extract at 20 ㎍/ml inhibited the viability of Raw264.7 by 50%. CR at 15 and 20 ㎍/ml showed a significant decrease in TNF-α levels from Raw264.7 cells treated with LPS. CR administration decreased arthritic index in DBA/1J mice immunized with bovine collagen type Π but it did not reach statistical significance. CR administration significantly decreased spleen weights obtained from mice in 6 weeks after immunization. CR administration significantly decreased serum anti-type Π collagen antibody levels compared with control group. CR administration decreased serum IL-6 levels compared with control group but it did not reach statistical significance. KCI Citation Count: 4