加味補陽還五湯의 抗血栓 및 抗炎作用에 대한 실험적 연구

• Published in: 동의생리병리학회지 Vol. 20; no. 4; pp. 957 - 965
• Main Authors: 이정은(Jung Eun Lee), 유동열(Dong Youl Yoo)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 01-08-2006
• Subjects: 한의학
• ISSN: 1738-7698; 2288-2529

This study was performed to evaluate antithrombotic activities and anti-inflammatory effects of Kami-BoyangHwanoh-Tang(KBHT). The major findings were summarized as follows. In experiment of anti-thrombotic effect; KBHT inhibited human platelet aggregation induced by ADP and epinephrine as compared with the control group and inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 50 %). KBHT increased platelet number significantly and also KBHT shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. In experiment of anti-inflammatory effect; KBHT inhibited IL-1β, IL-6, TNF-α, COX-2 and NOS-II mRNA expression as compared with the control group in a concentration-dependent degree, and inhibited NO production significantly at 50, 100 ㎍/㎖, and also inhibited ROS production in a concentration-dependent degree as compared with the control group in RAW 264.7 cell line. KBHT inhibited IL-1β, IL-6 and TNF-α production significantly in serum of acute inflammation-induced mice, and decreased IL-1β, IL-6 and TNF-α production in spleen tissue, and also decreased IL-6 and TNF-α production in liver tissue, but increased IL-1β production in liver tissue of acute inflammation-induced mice. KBHT increased survival rate at 3rd day in mice with lethal endotoxemia induced by LPS. These results suggest that KBHT can be useful in treating diverse female diseases caused by thrombosis and inflammation such as endometrosis, myoma, pelvic congestion, chronic cervicitis, chronic pelvic inflammatory disease and so on. KCI Citation Count: 8