Clinical value of soluble interleukin-2 receptor in infectious complications

In this study, we investigated serum-soluble interleukin-2 receptor (sIL-2r) and neopterin (NPT) levels in five patients with severe postoperative infections. A total of 25 synchronous determinations of sIL-2r and NPT were performed. A marked increase in sIL-2r and NPT levels was observed, and the i...

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Bibliographic Details
Published in:	Acta medica Okayama Vol. 48; no. 4; pp. 225 - 226
Main Authors:	Iwagaki, H, Hizuta, A, Iwadou, H, Perdomo, J A, Tanaka, N, Orita, K
Format:	Journal Article
Language:	English
Published:	Japan 01-08-1994
Subjects:	Aged Biopterins - analogs & derivatives Biopterins - blood Chromatography, High Pressure Liquid Female Humans Male Middle Aged Neopterin Peritonitis - blood Pneumonia - blood Postoperative Complications - blood Prognosis Receptors, Interleukin-2 - analysis
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Summary:	In this study, we investigated serum-soluble interleukin-2 receptor (sIL-2r) and neopterin (NPT) levels in five patients with severe postoperative infections. A total of 25 synchronous determinations of sIL-2r and NPT were performed. A marked increase in sIL-2r and NPT levels was observed, and the increase in sIL-2r was significantly correlated to that of NPT which is a marker of macrophage activity. These results suggest that macrophages are involved in the stimulation of sIL-2r release, representing a potentially negative biological effect. The results indicate that sIL-2r may be a useful indicator of the efficacy of antibiotics and of prognosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0386-300X