Effect of low dose cyclophosphamide on the synthesis of acute phase protein and its significance for cancer chemotherapy

Patients with far advanced colorectal cancers received chemotherapy consisting of low-dose cyclophosphamide (LDCY) 333 mg/m2 every four weeks intravenously and by oral administration of 5'-DFUR (a masked compound of 5-Fluorouracil). Serum levels of immunosuppressive acidic protein (IAP), an acu...

Full description

Saved in:

Bibliographic Details
Published in:	Acta medica Okayama Vol. 50; no. 5; p. 271
Main Authors:	Iwagaki, H, Hizuta, A, Fujiwara, T, Perdomo, J A, Tanaka, N, Orita, K
Format:	Journal Article
Language:	English
Published:	Japan 01-10-1996
Subjects:	Acute-Phase Proteins - biosynthesis Adenocarcinoma - blood Adenocarcinoma - drug therapy Administration, Oral Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Cyclophosphamide - administration & dosage Floxuridine - administration & dosage Humans Middle Aged Neoplasm Proteins - blood
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Patients with far advanced colorectal cancers received chemotherapy consisting of low-dose cyclophosphamide (LDCY) 333 mg/m2 every four weeks intravenously and by oral administration of 5'-DFUR (a masked compound of 5-Fluorouracil). Serum levels of immunosuppressive acidic protein (IAP), an acute phase protein, were measured every four weeks for a total of thirty-one LDCY trials of ten patients. LDCY chemotherapy significantly decreased the IAP levels in cancer patients with high IAP levels. These results suggested that LDCY chemotherapy could counteract host responses against tumors and could have decreased immunosuppressive responses in cancer patients.
ISSN:	0386-300X