Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family
Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the...
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| Published in: | Nature (London) Vol. 328; no. 6127; pp. 221 - 227 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Nature Publishing Group
16-07-1987
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| Abstract | Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor. |
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| AbstractList | Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor. Amino-acid sequences derived from DNAs that are encoding with a GABA/benzodiazepine from bovine brain show homology with the ligand-gated receptor subunits. Sequence and functional expression of the GABA A are discussed. |
| Author | Schofield, Peter R Burt, David R Ramachandran, J Rhee, Lucy M Seeburg, Peter H Barnard, Eric A Fujita, Norihisa Rodriguez, Henry Darlison, Mark G Stephenson, F. Anne Glencorse, Thora A Reale, Vincenzina |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/3037384$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright Macmillan Journals Ltd. Jul 16, 1987 |
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| DOI | 10.1038/328221a0 |
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| Snippet | Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology... Amino-acid sequences derived from DNAs that are encoding with a GABA/benzodiazepine from bovine brain show homology with the ligand-gated receptor subunits.... |
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| SubjectTerms | Animals Cattle Cloning, Molecular Deoxyribonucleic acid DNA DNA - genetics gamma-Aminobutyric Acid - physiology Gene Expression Regulation Genetics Membrane Proteins - genetics Multigene Family Oocytes - physiology Protein Conformation Receptors, GABA-A - genetics Receptors, GABA-A - physiology Receptors, Nicotinic - genetics |
| Title | Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family |
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