Asymmetric desymmetrization of meso-diols by C(2)-symmetric chiral 4-pyrrolidinopyridines

In this work we developed C(2)-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective acylation.

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Bibliographic Details
Published in:	Beilstein journal of organic chemistry Vol. 8; pp. 1778 - 1787
Main Authors:	Schedel, Hartmut, Kan, Keizo, Ueda, Yoshihiro, Mishiro, Kenji, Yoshida, Keisuke, Furuta, Takumi, Kawabata, Takeo
Format:	Journal Article
Language:	English
Published:	Germany 2012
Subjects:	nucleophilic catalyst organocatalysis meso-diol desymmetrization acylation hydrogen bond
Online Access:	Get full text
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Description
Summary:	In this work we developed C(2)-symmetric chiral nucleophilic catalysts which possess a pyrrolidinopyridine framework as a catalytic site. Some of these organocatalysts effectively promoted asymmetric desymmetrization of meso-diols via enantioselective acylation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1860-5397
DOI:	10.3762/bjoc.8.203