해동피를 포함한 한약제제 HPL-01의 Dextran sodium sulfate 유도 궤양성 대장염 완화 효과

• Published in: 동의생리병리학회지 Vol. 35; no. 2; pp. 64 - 70
• Main Authors: 조형권(Hyoung-Kwon Jo), 김대성(Dae-Sung Kim), 조성완(Seong-Wan Cho), 신나래(Na-Rae Shin), 박영미(Young Mi Park), 이학용(Hak Yong Lee), 신동엽(Dong-Yeop Shin)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2021
• Subjects: 한의학; Colon length; Herbal complex HPL-01; TNF-α; Dextran sulfate sodium; IL-6; Ulcerative colitis; TNF-{\alpha}
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2021.02.35.2.64

This study aimed to investigate the anti-inflammatory effects of herbal complex HPL-01 on dextran sodium sulfate(DSS) induced ulcerative colitis in rat. Adult male Sprague-Dawley rats were randomized and divided into six groups. Five groups, excluding the normal group, were orally administered orally HPL-01(50, 100, or 200 mg/kg) for 21 days, and acute colitis was induced during the last 7 days by 4% DSS in the drinking water. The HPL-01 administered DSS-treated rats exhibited significantly reduced colon macroscopic damage index and increased body weight and colonic length 7 days after DSS treatment. Additionally, these rats showed lower serum levels of the pro-inflammatory cytokines TNF-α and IL-6 than those treated only with DSS. HPL-01(100 or 200 mg/kg) also attenuated the DSS-induced increase in the number of white blood cells, granulocytes, and mid cells and improved intestinal damage. Taken together, these results suggest that HPL-01 is a promising anti-inflammatory agent that may be in the treatment of colitis.