백서 좌골신경에 시행한 박동성 고주파술 ( Pulsed Radiofrequency )이 급성 통증과 신경조직에 미치는 영향

• Published in: The Korean journal of pain Vol. 13; no. 2; pp. 149 - 155
• Main Authors: 이기헌, Kee Heon Lee, 신근만, Keun Man Shin, 권경석, Kyoung Seok Kweon, 정배희, Bae Hee Jung, 임소영, So Young Lim, 홍순영, Soon Yong Hong, 최영희, Young Hee Choi, 박영의, Young Euy Park
• Format: Journal Article
• Language: Korean
• Published: 대한통증학회 2000
• Subjects: Pain: acute; neuropathologic changes; Surgery: pulsed radiofrequency lesion; Research: hot-plate test
• ISSN: 2005-9159; 1226-2579; 2093-0569

Background: Pulsed radiofrequency (RF) lesioning is a painless procedure and causes no neurodestruction and neuritis-like reaction are common following conventional RF lesioning. There is little data about the effect of pulsed RF especially with regard to its suitability for the treatment of acute pain. The possibility of a placebo effect cannot be ruled out because a double-blind study was not performed in previous studies. There is also no neuropathologic study about pulsed RF. Methods: The rats were anesthetized with sodium pentobarbital (40 mg/kg, i.p.; supplemented as necessary). The common sciatic nerve was exposed by blunt dissection through biceps femoris. Pulsed RF was administered to the common sciatic nerve using a 30 ms/s pulse with for 120 seconds. The temperature reached was no more than 42℃. Analgesia was determined using hot-plate assay shortly and, 3 days and 1 week before, and 2 weeks after operation. Lesions were examined with LM (light microscope) and EM (electron microscope) 2 weeks later. Results: There were no differences in response latencies between the control and experimental group. There were many vacuoles with hyaline bodies in the Schwann cell cytoplasm rather than axon in LM and larger electron dense bodies. No changes were found in the axon or unmyelinated fibers. Only small changes were found in the sheaths of myelinated fibers and Schwann cells. Conclusions: We therefore do think that any analgesic effect of pulsed RF is not a result of block of neural conduction. But rather than it can be attributed to others factors. It was also ineffective as a treatment for acute pain such as that caused by the hot-plate test.