림프종으로 오인된 댑손에 의한 drug reaction with eosinophilia and systemic symptoms 증후군 1예

• Published in: Allergy asthma & respiratory disease pp. 400 - 404
• Main Authors: 신보미, 박소영(서울아산병원, 윤선영(서울아산병원, 신은혜, 양영주, 조형진, 장일영, 강동욱, 김태범, 조유숙, 문희범, 권혁수
• Format: Journal Article
• Language: Korean
• Published: 대한 소아알레르기 호흡기학회 30-12-2013
• Subjects: 소아과학
• ISSN: 2288-0402; 2288-0410

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction with systemic manifestations. Dapsone is known to be useful for treatment of leprosy and various dermatologic conditions. We report a patient with prurigo pigmentosa who developed DRESS syndrome after dapsone treatment. She presented with lymphadenopathy, fever, eosinophilia, skin rash, and elevated liver enzymes. Initial lymph node and skin biopsy was suggestive of peripheral T-cell lymphoma. Initially, she was treated with chemotherapy. A week later after complete remission of skin symptoms, new skin lesions recurred. TCR-gene rearrangement was examined to show negative results and she was diagnosed as dapsone induced DRESS syndrome. This case emphasizes the importance of differential diagnosis of lymphoma and DRESS syndrome. KCI Citation Count: 0