ANTITUMOR ACTIVITY OF ASTERRIQUINONE, A METABOLIC PRODUCT FROM ASPERGILLUS TERREUS

Asterriquinone isolated from the mycelium of Aspergillus terreus was tested for its antitumor activity. This compound was very effective against Ehrlich carcinoma and ascites hepatoma, AH-13, in vivo, while slightly effective against Yoshida sarcoma and L-1210 leukemia. Some modifications in the mol...

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Bibliographic Details
Published in:	GANN Japanese Journal of Cancer Research Vol. 67; no. 4; pp. 623 - 624
Main Authors:	YAMAMOTO, Yuzuru, KIRIYAMA, Noriki, SHIMIZU, Sakae, KOSHIMURA, Saburo
Format:	Journal Article
Language:	English
Published:	Japan The Japanese Cancer Association 01-01-1976
Subjects:	Animals Antineoplastic Agents - isolation & purification Antineoplastic Agents - therapeutic use Antitumor activity Ascites hepatoma, AH-13 Aspergillus - analysis Aspergillus terreus Asterriquinone Carcinoma, Ehrlich Tumor - drug therapy Dose-Response Relationship, Drug Ehrlich carcinoma Lethal Dose 50 Leukemia L-1210 Mice Quinones - isolation & purification Quinones - therapeutic use Yoshida sarcoma
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Summary:	Asterriquinone isolated from the mycelium of Aspergillus terreus was tested for its antitumor activity. This compound was very effective against Ehrlich carcinoma and ascites hepatoma, AH-13, in vivo, while slightly effective against Yoshida sarcoma and L-1210 leukemia. Some modifications in the molecule resulted in entire loss of its activity.
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.67.4_623