Synthesis and modification of a novel 1 beta-methyl carbapenem antibiotic, S-4661

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 49; no. 5; p. 478
Main Authors:	Iso, Y, Irie, T, Iwaki, T, Kii, M, Sendo, Y, Motokawa, K, Nishitani, Y
Format:	Journal Article
Language:	English
Published:	Japan 01-05-1996
Subjects:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Carbapenems - chemical synthesis Carbapenems - chemistry Carbapenems - pharmacology Doripenem Microbial Sensitivity Tests Stereoisomerism Structure-Activity Relationship
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Description
Summary:	We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.49.478