Enhancement of tumor response to γ-radiation by an inhibitor of cyclooxygenase-2 enzyme

• Published in: JNCI : Journal of the National Cancer Institute Vol. 91; no. 17; pp. 1501 - 1504
• Main Authors: MILAS, L, KISHI, K, HUNTER, N, MASON, K, MASFERRER, J. L, TOFILON, P. J
• Format: Journal Article
• Language: English
• Published: Cary, NC Oxford University Press 01-09-1999; Oxford Publishing Limited (England)
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Cancer; Combined treatments (chemotherapy of immunotherapy associated with an other treatment); Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors - pharmacology; Enzymes; Gamma Rays; Isoenzymes - drug effects; Medical sciences; Mice; Neovascularization, Pathologic - prevention & control; Pharmacology. Drug treatments; Prostaglandin-Endoperoxide Synthases - drug effects; Pyrazoles - pharmacology; Radiation; Radiation-Sensitizing Agents - pharmacology; Sarcoma, Experimental - blood supply; Sarcoma, Experimental - drug therapy; Sarcoma, Experimental - radiotherapy; Sulfonamides - pharmacology; Tumors; Animal model; Prostaglandin-endoperoxide synthase; Sarcoma; Enzyme; Rodentia; Malignant tumor; Radiotherapy; Vertebrata; Chemotherapy; Mammalia; Gamma radiation; Treatment; Mouse; Animal; Inhibitor; Combined treatment; Oxidoreductases
• ISSN: 0027-8874; 1460-2105
• DOI: 10.1093/jnci/91.17.1501

Prostaglandins are involved in the response of tumor and normal tissues to cytotoxic agents such as ionizing radiation. Prostaglandin production is mediated by two cyclooxygenase enzymes: cyclooxygenase-1 and cyclooxygenase-2.