ERK MAP kinase in G1 cell cycle progression and cancer

The extracellular‐signal‐regulated kinase (ERK) mitogen‐activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses, including cell proliferation, cell differentiation and cell survival. Recent studies have identified a number of Ras/ERK signaling‐related p...

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Bibliographic Details
Published in:	Cancer science Vol. 97; no. 8; pp. 697 - 702
Main Authors:	Torii, Satoru, Yamamoto, Takuya, Tsuchiya, Yoshiki, Nishida, Eisuke
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Publishing Asia 01-08-2006 Blackwell
Subjects:	Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens General aspects Medical sciences Review Tumors Human G1 Phase Cancerology Extracellular signal-regulated protein kinase Enzyme Malignant transformation Cell cycle Mitogen-activated protein kinase Review Malignant tumor Carcinogenesis Cancer
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Summary:	The extracellular‐signal‐regulated kinase (ERK) mitogen‐activated protein (MAP) kinase signaling pathway plays an important role in various cellular responses, including cell proliferation, cell differentiation and cell survival. Recent studies have identified a number of Ras/ERK signaling‐related proteins, such as scaffold proteins and inhibitors. These proteins modulate ERK signaling and thereby could give variations in ERK signaling outputs that regulate cell fate decisions. Here we focus on the role of ERK signaling in cell cycle progression from G0/G1 to S phase and cancer. (Cancer Sci 2006; 97: 697–702)
ISSN:	1347-9032 1349-7006
DOI:	10.1111/j.1349-7006.2006.00244.x