Beyond Nuclear Transport: Ran-GTP as a Determinant of Spindle Assembly

The observation that the GTP-bound form of Ran can stimulate microtubule polymerization offers a significant insight into the process by which chromosomes drive spindle assembly, especially in the absence of microtubule-organizing centers.

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 146; no. 6; pp. 1205 - 1209
Main Authors:	Kahana, Jason A., Cleveland, Don W.
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 20-09-1999 The Rockefeller University Press
Subjects:	Animals Biological Transport Cell Cycle Cell Nucleus - metabolism Cells Cellular biology Centrosomes Chromatin Chromosomes Cytoplasm Gene expression regulation GTP-Binding Proteins - metabolism Guanosine Triphosphate - metabolism Hydrolysis Microtubules Microtubules - metabolism Mini-Review Mitosis Mitotic spindle apparatus Models, Biological Nuclear Proteins - metabolism Proteins ran GTP-Binding Protein Spindle Apparatus - metabolism Xenopus laevis
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Description
Summary:	The observation that the GTP-bound form of Ran can stimulate microtubule polymerization offers a significant insight into the process by which chromosomes drive spindle assembly, especially in the absence of microtubule-organizing centers.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0021-9525 1540-8140
DOI:	10.1083/jcb.146.6.1205