CLINICAL STUDIES ON CEFTIZOXIME IN THE RESPIRATORY TRACT INFECTION

• Published in: CHEMOTHERAPY Vol. 28; no. Supplement5; pp. 305 - 310
• Main Authors: TANIMOTO, HIROICHI, TACHIBANA, AKIO, SUZUKI, MIKIZOU, NAKATA, KOICHIRO, OKANO, HIROSHI, TAKIZAWA, MASAKO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 01-01-1980
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.28.Supplement5_305

Clinical effectiveness and adverse effects of ceftizoxime, a new cephalosporin antibiotic, were studied in 12 patients with the respiratory tract infections receiving 1 to 3g b. i. d. by drip infusion. There were 9 cases of lower resniratory tract infection. 2 cases of nneumonia and 1 case of lung abscess. The treatment was markedly effective in 3 patients, moderately effective in 3, slightly effective in 2 and ineffective in the remaining 4, thus producing slight to marked clinical improvement in 67% of the cases studied. The ceftizoxime therapy was effective in all 5 cases of respiratory tract infection with H. influenza whereas it failed to bring about any significant bacteriological improvement in any of 4 cases of respiratory tract infection by glucose non-fermentative gram negative bacilli. In a case of pneumonia due to S. marcescens refractory to other antimicrobial chemotherapy, a bignificant clinical improvement was achieved by administration of ceftizoxime, 3 g b. i. d. None developed any serious adverse effects. The results indicate usefulness of ceftizoxime in the treatment of respiratory tract infection.