ANTIMICROBIAL ACTIVITY AND CLINICAL STUDIES OF HAPA-B IN THE FIELD OF SURGERY

ANTIMICROBIAL ACTIVITY AND CLINICAL STUDIES OF HAPA-B IN THE FIELD OF SURGERY

HAPA-B, a new aminoglycoside antibiotics, was investigated on its antimicrobial activity against clinical isolates, clinical efficacy and side effects. 1) HAPA-B was more active than gentamicin against E. coli, and was as active as gentamicin against Kiebsiella, Enterobacter, Serratia, and P. aerugi...

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Published in:CHEMOTHERAPY Vol. 33; no. Supplement5; pp. 411 - 419
Main Authors: UEDA, TAKAMI, SAKAI, KATSUJI, FUJIMOTO, MIKIO, MAEDA, SADAKUNI, DOI, SUSUMU, MITSUYOSHI, KIYOSI, SAWADA, AKIRA, MATSUMOTO, KEINOSUKE, MORIMOTO, YUZURU
Format: Journal Article
Language:English
Japanese
Published: Japanese Society of Chemotherapy 1985
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Abstract HAPA-B, a new aminoglycoside antibiotics, was investigated on its antimicrobial activity against clinical isolates, clinical efficacy and side effects. 1) HAPA-B was more active than gentamicin against E. coli, and was as active as gentamicin against Kiebsiella, Enterobacter, Serratia, and P. aeruginosa. 2) HAPA-B was administered to 21 patients with various surgical infections, such as peritonitis, postoperative intraabdominal infection, wound infection, adscess, postoperative intrathoracic infection, postoperative cholangitis, sepsis and cellulitis. The results obtained were excellent in 5, good in 11, fair in 1, poor in 3 and unknown in 1 patient (efficacy rate: 80.0 %). Particularly satisfactory results were seen in abscess, wound infection and cellulitis. 3) Side effects noted in one patient each were eruption, weakness and increasing of tinnitus, eosinophilia and hepatic disorder (GOT, GPT elevation).
AbstractList HAPA-B, a new aminoglycoside antibiotics, was investigated on its antimicrobial activity against clinical isolates, clinical efficacy and side effects. 1) HAPA-B was more active than gentamicin against E. coli, and was as active as gentamicin against Kiebsiella, Enterobacter, Serratia, and P. aeruginosa. 2) HAPA-B was administered to 21 patients with various surgical infections, such as peritonitis, postoperative intraabdominal infection, wound infection, adscess, postoperative intrathoracic infection, postoperative cholangitis, sepsis and cellulitis. The results obtained were excellent in 5, good in 11, fair in 1, poor in 3 and unknown in 1 patient (efficacy rate: 80.0 %). Particularly satisfactory results were seen in abscess, wound infection and cellulitis. 3) Side effects noted in one patient each were eruption, weakness and increasing of tinnitus, eosinophilia and hepatic disorder (GOT, GPT elevation).
Author DOI, SUSUMU
MAEDA, SADAKUNI
MATSUMOTO, KEINOSUKE
SAWADA, AKIRA
MITSUYOSHI, KIYOSI
FUJIMOTO, MIKIO
UEDA, TAKAMI
MORIMOTO, YUZURU
SAKAI, KATSUJI
Author_xml – sequence: 1
  fullname: UEDA, TAKAMI
  organization: The Second Department of Surgery, Osaka City University Medical School
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  fullname: SAKAI, KATSUJI
  organization: The Second Department of Surgery, Osaka City University Medical School
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  fullname: FUJIMOTO, MIKIO
  organization: The Second Department of Surgery, Osaka City University Medical School
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  fullname: MAEDA, SADAKUNI
  organization: Department of Surgery, Fujiidera Domyoji Hospital
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  fullname: DOI, SUSUMU
  organization: Departnent of Surgery, Osaka City Kita Hospital
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  fullname: MITSUYOSHI, KIYOSI
  organization: Department of Surgery, Osaka City Momoyama Hospital
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  fullname: SAWADA, AKIRA
  organization: Department of Surgery, Keio Hospital
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  fullname: MATSUMOTO, KEINOSUKE
  organization: Department of Surgery, Joto-Chuo Hospital
– sequence: 9
  fullname: MORIMOTO, YUZURU
  organization: Department of Surgery, Higashisumiyoshi-Morimoto Hospital
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References 3) 藤本幹夫, 他: 外科領域におけるGentamicinの臨床使用成績. Jap. J. Antibiotics 29: 273-282, 1976
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1) 第31回日本化学療法学会東日本支部総会, 新薬シンポジウム, HAPA-B, 1984
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