ANTIMICROBIAL ACTIVITY AND CLINICAL STUDIES OF HAPA-B IN THE FIELD OF SURGERY

• Published in: CHEMOTHERAPY Vol. 33; no. Supplement5; pp. 411 - 419
• Main Authors: UEDA, TAKAMI, SAKAI, KATSUJI, FUJIMOTO, MIKIO, MAEDA, SADAKUNI, DOI, SUSUMU, MITSUYOSHI, KIYOSI, SAWADA, AKIRA, MATSUMOTO, KEINOSUKE, MORIMOTO, YUZURU
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1985
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.33.Supplement5_411

HAPA-B, a new aminoglycoside antibiotics, was investigated on its antimicrobial activity against clinical isolates, clinical efficacy and side effects. 1) HAPA-B was more active than gentamicin against E. coli, and was as active as gentamicin against Kiebsiella, Enterobacter, Serratia, and P. aeruginosa. 2) HAPA-B was administered to 21 patients with various surgical infections, such as peritonitis, postoperative intraabdominal infection, wound infection, adscess, postoperative intrathoracic infection, postoperative cholangitis, sepsis and cellulitis. The results obtained were excellent in 5, good in 11, fair in 1, poor in 3 and unknown in 1 patient (efficacy rate: 80.0 %). Particularly satisfactory results were seen in abscess, wound infection and cellulitis. 3) Side effects noted in one patient each were eruption, weakness and increasing of tinnitus, eosinophilia and hepatic disorder (GOT, GPT elevation).