A case of bronchiectasis accompanied by ulcerative colitis (UC) and HTLV-1 associated myelopathy (HAM)

• Published in: Nihon Kyōbu Shikkan Gakkai zasshi Vol. 32; no. 4; p. 358
• Main Authors: Suzuki, I, Watanabe, N, Suzuki, J, Yamaguchi, E, Munakata, M, Fujita, M
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-04-1994
• Subjects: Adult; Bronchiectasis - etiology; Colitis, Ulcerative - complications; Humans; Male; Paraparesis, Tropical Spastic - complications
• ISSN: 0301-1542
• DOI: 10.11389/jjrs1963.32.358

We report a case of bronchiectasis with marked thickening of the respiratory tract wall occurring in a 37-year-old man with UC and HAM. He was diagnosed as UC at age 20. HTLV-1 was presumably transmitted to this patient by means of a blood transfusion he received at around age 30. On admission, chest X-ray films, tomography and CT-scan revealed dilated lumens and thickened airway walls extending from the trachea to subsegmental bronchi. Pulmonary function tests showed hypoxemia and mixed ventilatory disturbance with a predominantly obstructive component. HAM was diagnosed on the basis of neurological examination and cerebrospinal fluid analysis. A biopsy specimen from the carinal mucosa showed marked T cell infiltration. In these T cells, we detected polyclonal integration of HTLV-1 proviral DNA. Some of the infiltrating T cells showed atypia. In recent times, respiratory diseases other than infiltration of adult T-cell leukemia cells or opportunistic infection have been reported in HTLV-1 carriers and new clinical entities designated as HABA (HTLV-1 associated bronchiolo-alveolar disorder) and HBA (HTLV-1 associated bronchopneumopathy) have been proposed. This case is classified among these new entities, in a broad sense, and is a rare case in that the respiratory disorder is apparently related to UC.