EFFECT OF ANTIBIOTICS ON PHAGOCYTOSIS AND BACTERICIDAL ACTIVITY OF HUMAN LEUCOCYTES
To examine the effect of antibiotics on phagocytosis and bactericidal activity of human neutrophils in vitro, 17 antibiotics and 2 antibacterial agents were tested using peripheral neutrophils from normal subjects or patients with complicated pyelonephritis. The effect on phagocytosis was measured b...
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| Published in: | CHEMOTHERAPY Vol. 34; no. 2; pp. 157 - 164 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English Japanese |
| Published: |
Japanese Society of Chemotherapy
1986
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| Online Access: | Get full text |
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| Summary: | To examine the effect of antibiotics on phagocytosis and bactericidal activity of human neutrophils in vitro, 17 antibiotics and 2 antibacterial agents were tested using peripheral neutrophils from normal subjects or patients with complicated pyelonephritis. The effect on phagocytosis was measured by counting engulfed cocci by microscopy, or those which had been labeled with 3H-Lysine with a liquid scintillation counter. Bactericidal activity was measured by QUIE's method. The effect of antibiotics on phagocytosis and bactericidal activity varied with the kind and concentration of antibiotic used. While many antibiotics suppressed phagocytosis and bactericidal activity below the normally clinically accepted maximum concentration levels in blood, CPIZ enhanced these activities markedly, in which the effect of antibiotics differed normal subjects and patients with pyelonephritis. |
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| ISSN: | 0009-3165 1884-5894 |
| DOI: | 10.11250/chemotherapy1953.34.157 |