MnO2 Gatekeeper: An Intelligent and O2‐Evolving Shell for Preventing Premature Release of High Cargo Payload Core, Overcoming Tumor Hypoxia, and Acidic H2O2‐Sensitive MRI

• Published in: Advanced functional materials Vol. 27; no. 4
• Main Authors: Ma, Zhifang, Jia, Xiaodan, Bai, Jing, Ruan, Yudi, Wang, Chao, Li, Jianming, Zhang, Mengchao, Jiang, Xiue
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 26-01-2017
• Subjects: Bioaccumulation; Cargo; Condensation; Diagnostic software; Diagnostic systems; Evolution; Hypoxia; Magnetic resonance imaging; Materials science; Methylene blue; MnO2 shell; MRI; Nanocomposites; NMR; Nuclear magnetic resonance; oxygen generation; PDT; Photodynamic therapy; premature leakage; Shields; Silicon dioxide
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.201604258

Premature leakage of photosensitizer (PS) from nanocarriers significantly reduces the accumulation of PS within a tumor, thereby enhancing nonspecific accumulation in normal tissues, which inevitably leads to a limited efficacy for photodynamic therapy (PDT) and the enhanced systematic phototoxicity. Moreover, local hypoxia of the tumor tissue also seriously hinders the PDT. To overcome these limitations, an acidic H2O2‐responsive and O2‐evolving core–shell PDT nanoplatform is developed by using MnO2 shell as a switchable shield to prevent the premature release of loaded PS in core and elevate the O2 concentration within tumor tissue. The inner core SiO2‐methylene blue obtained by co‐condensation has a high PS payload and the outer MnO2 shell shields PS from leaking into blood after intravenous injection until reaching tumor tissue. Moreover, the shell MnO2 simultaneously endows the theranostic nanocomposite with redox activity toward H2O2 in the acidic microenvironment of tumor tissue to generate O2 and thus overcomes the hypoxia of cancer cells. More importantly, the Mn(ΙΙ) ion reduced from Mn(ΙV) is capable of in vivo magnetic resonance imaging selectively in response to overexpressed acidic H2O2. The facile incorporation of the switchable MnO2 shell into one multifunctional diagnostic and therapeutic nanoplatform has great potential for future clinical application.
Premature leakage of photosensitizer (PS) from nanocarriers reduces the accumulation of PS within tumor, leading to a limited efficacy for photodynamic therapy (PDT). Moreover, local hypoxia of tumor also seriously hinders the PDT. To overcome these limitations, an acidic H2O2‐responsive MnO2 shell is introduced to prevent the premature release of PS and simultaneously elevate O2 concentration within the tumor.