CLINICAL TRIALS OF KW-1062 IN THE FIELD OF SURGERY
KW-1062 was tried on acute cases with various infections in the field of surgery, and effective responses were seen on 11 of all the 16 patients. Untoward side effects were experienced on 2 cases : an uncomfortable sensation in the chest immediately after an intramuscular injection on one case, and...
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| Published in: | CHEMOTHERAPY Vol. 25; no. 7; pp. 2122 - 2127 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English Japanese |
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Japanese Society of Chemotherapy
1977
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| Abstract | KW-1062 was tried on acute cases with various infections in the field of surgery, and effective responses were seen on 11 of all the 16 patients. Untoward side effects were experienced on 2 cases : an uncomfortable sensation in the chest immediately after an intramuscular injection on one case, and dermal rash on the other. In addition, serum levels and urinary excretion were investigated in healthy male volunteers. KW-1062 is a new promising antibiotic effective for acute infections, especially caused by gram negative rods including Pseudomonas aeruginosa in the field of surgery. |
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| AbstractList | KW-1062 was tried on acute cases with various infections in the field of surgery, and effective responses were seen on 11 of all the 16 patients. Untoward side effects were experienced on 2 cases : an uncomfortable sensation in the chest immediately after an intramuscular injection on one case, and dermal rash on the other. In addition, serum levels and urinary excretion were investigated in healthy male volunteers. KW-1062 is a new promising antibiotic effective for acute infections, especially caused by gram negative rods including Pseudomonas aeruginosa in the field of surgery. |
| Author | HIRAO, SATORU DOI, SUSUMU KAWABATA, NORIYUKI FUJIMOTO, MIKIO UEDA, TAKAMI SAKAI, KATSUJI SHIRAHA, YAEMON |
| Author_xml | – sequence: 1 fullname: SHIRAHA, YAEMON organization: Second Department of Surgery, Osaka City University Medical School – sequence: 2 fullname: SAKAI, KATSUJI organization: Second Department of Surgery, Osaka City University Medical School – sequence: 3 fullname: FUJIMOTO, MIKIO organization: Second Department of Surgery, Osaka City University Medical School – sequence: 4 fullname: UEDA, TAKAMI organization: Second Department of Surgery, Osaka City University Medical School – sequence: 5 fullname: HIRAO, SATORU organization: Second Department of Surgery, Osaka City University Medical School – sequence: 6 fullname: KAWABATA, NORIYUKI organization: Department of Surgery, Osaka City Kita Hospital – sequence: 7 fullname: DOI, SUSUMU organization: Department of Surgery, Osaka City Kita Hospital |
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| References | 3) EGAN, R. S.; R. L. DEVAULT, S. L. MUELLER, M. I. LEVENBERG, A. C. SINCLAIR & R. S. STANASZEK : A new antibietic XK-62-2. III. Thestructure of XK-62-2, a new gentamicin Ccomplex antibiotic.J.Antibiotics 28 (1) : 29-34, 1975 4) 第23回日本化学療法学会東日本支部総会, 新薬シンポジウムII, KW-1062, 1976 2) NARA, T.; I. KAWAMOTO, R. OKACHI, S. TAKASAWA, M. YAMAMOTO, S. SATO, T. SATO & A. MORIKAWA : New antibiotic XK-62-2 (Sagamicin). II. Taxonomy of the producing organism, fermentative production and characterization of sagamicin. J. Antibiotics 28 (1) : 21-28, 1975 1) OKACHI, R.; I. KAWAMOTO, S. TAKASAWA, M. YAMAMOTO, S. SATO, T. SATO & T. NARA : A new antibiotic XK-62-2 (Sagamicin). I. Isolation, physicochemical and antibacterial properties. J. Antibiotics 27 (10) : 793-800, 1974 |
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| Snippet | KW-1062 was tried on acute cases with various infections in the field of surgery, and effective responses were seen on 11 of all the 16 patients. Untoward side... |
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| Title | CLINICAL TRIALS OF KW-1062 IN THE FIELD OF SURGERY |
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