Clinical trials of flomoxef in complicated urinary tract infections

• Published in: Japanese journal of antibiotics Vol. 40; no. 10; p. 1835
• Main Authors: Ohta, N, Sudoko, H, Fukuta, K, Nakano, M, Ushiyama, T, Tajima, A, Aso, Y, Masuda, H, Suzuki, A, Suzuki, K
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-10-1987
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Infective Agents, Urinary - administration & dosage; Anti-Infective Agents, Urinary - adverse effects; Anti-Infective Agents, Urinary - therapeutic use; Bacteria - isolation & purification; Cephalosporins - administration & dosage; Cephalosporins - adverse effects; Cephalosporins - therapeutic use; Drug Evaluation; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Urinary Tract Infections - complications; Urinary Tract Infections - drug therapy; Urinary Tract Infections - microbiology
• ISSN: 0368-2781
• DOI: 10.11553/antibiotics1968b.40.1835

Flomoxef (6315-S, FMOX), a new oxacephem antibiotic was studied clinically in 27 patients with complicated urinary tract infections. FMOX was intravenously administered at a dose of 1.0 g twice daily for 5 days. Clinical effect of FMOX on patients with complicated urinary tract infections were excellent in 11.5%, moderate in 57.7% and overall clinical efficacy rate was 69.2%. During the treatment with FMOX, urticaria was observed in 1 case. In laboratory tests, a decrease of RBC, Hb and Ht in 1 case, a decrease of WBC in 1 case and an elevation of GPT in another case were observed. But these abnormal values were slight and transient.