Urinary excretion of kallikrein and prostaglandins before and after sodium deprivation and their relationships to plasma vasopressive substances

• Published in: Nihon Jinzo Gakkai shi Vol. 29; no. 10; pp. 1215 - 1222
• Main Authors: NIGAWARA, KAZUO, KAWAGUCHI, TOSHIAKI, YANAGIYA, HITOSHI, TODA, TADAO, SUZUKI, TADASHI, FUNYU, TOMIHISA, TERAYAMA, YURIKO, YAMAYA, KANEMITSU, IGARASHI, RYUKO
• Format: Journal Article
• Language: Japanese
• Published: Japan Japanese Society of Nephrology 01-10-1987
• Subjects: Adult; Aldosterone - blood; Aldosterone - urine; Diet, Sodium-Restricted; Humans; Kallikreins - urine; Male; Norepinephrine - blood; plasma norepinephrine; Prostaglandins - urine; Renin - blood; renin-angiotensin-aldosterone system; sodium deprivation; Spironolactone - pharmacology; urinary kallikrein; urinary prostaglandins
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.29.1215

To investigate the relationship of urinary excretion of kallikrein and prostaglandin to plasma vasopressive substances, twenty-four-hour urine in 5 normal subjects were collected under the conditions of normal sodium diet, low sodium diet and low sodium diet plus spironolactone (SP), including every-two-hour urine and peripheral blood both at recumbency and at upright posture. Besides urinary excretion of sodium, kallikrein (UKa1V), prostaglandin E2 (UPGE2V) and F (UPGFV), plasma levels of renin activity, aldosterone (PAC), and norepinephrine (PNEC) were also measured. Consequently UKa1V increased under the condition of low sodium diet and decreased by the admistration of SP, while UPGE2V increased with the enhencement of sodium deficiency, but UPGFV did not show any marked change. UKa1V, UPGE2V and UPGFV increased under the three-different sodium status at upright posture. From the correlation between these results and the plasma vasopressive substances, it was suggested that UKa1V was related to the effective concentration of PAC and slightly to that of PNEC, while UPGE2V was related to renin-angiotensin system to some extent but not to PNEC. The production process of PGF seemed to be different from that of PGE2.