Molecular mechanisms for intracellular parasitisation and exclusion in macrophage infected with Mycobacterium leprae

It was previously demonstrated that TLR2 and CORO1A (TACO, Coronin 1, p57) localize phagosome membrane of macrophage. However, the functional relationship between TLR2 and CORO1A was not known. We show here that there is a functional counteraction between TLR2 and CORO1A.

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Bibliographic Details
Published in:	Nihon Hansenbyō Gakkai zasshi Vol. 77; no. 1; p. 57
Main Authors:	Tanigawa, Kazunari, Suzuki, Koichi, Kawashima, Akira, Mishima, Masayo, Wu, Huhehasi, Akama, Takeshi, Takeshita, Fumihiko, Ishii, Norihisa
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-02-2008
Subjects:	Cells, Cultured Humans Leprosy - genetics Leprosy - microbiology Macrophages - immunology Macrophages - microbiology Microfilament Proteins - physiology Mycobacterium leprae Phagosomes - genetics Signal Transduction - physiology Skin - cytology Toll-Like Receptor 2 - physiology
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Description
Summary:	It was previously demonstrated that TLR2 and CORO1A (TACO, Coronin 1, p57) localize phagosome membrane of macrophage. However, the functional relationship between TLR2 and CORO1A was not known. We show here that there is a functional counteraction between TLR2 and CORO1A.
ISSN:	1342-3681
DOI:	10.5025/hansen.77.57