Intra-abdominal recurrence with bleeding 7 years after curative resection of primary synovial sarcoma of the spermatic cord with localized dissemination:a case report

• Published in: Nippon Shōkakibyō Gakkai zasshi Vol. 118; no. 12; p. 1130
• Main Authors: Shimojima, Yukio, Hirose, Yuki, Takano, Kabuto, Nomura, Tatsuya, Ando, Takuya, Kawasaki, Takashi, Banba, Takeo, Nogami, Hitoshi, Takii, Yasumasa, Yabusaki, Hiroshi, Nakagawa, Satoru
• Format: Journal Article
• Language: Japanese
• Published: Japan 10-12-2021
• Subjects: Aged; Chemotherapy, Adjuvant; Hemorrhage - etiology; Hemorrhage - surgery; Humans; Male; Sarcoma, Synovial - diagnostic imaging; Sarcoma, Synovial - surgery; Spermatic Cord - diagnostic imaging; Spermatic Cord - surgery
• ISSN: 0446-6586
• DOI: 10.11405/nisshoshi.118.1130

Primary synovial sarcoma of the spermatic cord is quite rare and has not been reported in Japanese literature. We report a case of primary synovial sarcoma of the spermatic cord and localized dissemination of the tumor in a patient who experienced recurrence of intra-abdominal bleeding 7 years after curative resection of the primary lesion. A 70-year-old man was admitted with disturbance on urination and lower abdominal pain. Computed tomography (CT) of the abdomen revealed two lesions:a 10-cm intrapelvic tumor with hemorrhage and a 4-cm tumor adjacent to the bladder. Curative excision of the tumors was performed. Histological examination revealed that the larger lesion was a primary tumor of the spermatic cord with proliferation of spindle cells in cellular fascicles in a monotonous pattern, which was compatible with histologic findings of monophasic fibrous synovial sarcoma. The smaller lesion was a disseminated tumor. The diagnosis of synovial sarcoma was confirmed by the detection of a SS18 (SYT) -SSX1 fusion gene. After discharge, the patient received adjuvant chemotherapy, including ifosfamide and doxorubicin. No recurrence was evident thereafter. Seven years after the operation, the patient experienced sudden abdominal pain and swelling and was transferred to our hospital. CT showed a 17-cm tumor with massive hemorrhage in the omental bursa. Through catheterization of the superior mesenteric artery, bleeding from a branch of the dorsal pancreatic artery was identified. Because of the difficulty of catheterizing the bleeding branch, he underwent emergency resection of the tumor and partial resection of the colon. Histologic examination and genetic testing revealed that the tumor was a recurrence of the synovial sarcoma. After discharge, the patient received treatment with gemcitabine and docetaxel. However, 7 months after the second surgery, intraperitoneal manifestations recurred. The patient died 14 months after the second resection. This case suggests that curative surgical resection of the primary synovial sarcoma of the spermatic cord contributes to prolonged survival. However, because the recurrence rate of synovial sarcoma is high, multidisciplinary treatment, including chemotherapy and radiotherapy, might be necessary.