CLINICAL EXPERIENCE OF CEFSULODIN (SCE-129) AGAINST COMPLICATED URINARY TRACT INFECTION CAUSED BY PSEUDOMONAS AERUGINOSA

• Published in: CHEMOTHERAPY Vol. 27; no. Supplement2; pp. 380 - 384
• Main Authors: KUMAZAWA, JOICHI, MOMOSE, SHUNRO, KURODA, NORIYUKI, OMOTO, TETSUO, NAKAYAMA, KEN, HIEDA, SADAMU
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 25-03-1979
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.27.Supplement2_380

1. Cefsulodin (SCE-129, CFS) was administered to the cases of complicated urinary tract infection caused by Pseudomonas aeruginosa for the hospitalized patients in the departments of urology at Kyushu University, Kyushu Kosei Nenkin Hospital and Miyazaki Prefectural Hospital. 2. CFS was administered to 15 cases, however, Pseudomonas aeruginosa was disappeared in 2 cases prior to medication. 3. The period of administration was 5 days except for 1 case of 7 days and 2 cases of 10 days. The route of administration was intravenous drip in 12 cases with 500 mg twice per day and 2 cases with 1, 000 mg twice per day except for another case of intramuscular injection of 250 mg twice per day. 4. The efficacy rate was 47% with markedly effective in 2 cases, effective in 5 cases and non effective in 8 cases. 5. Pseudomonas aeruginosa was isolated in 13 cases of which 2 cases were markedly effective, 4 cases effective and 7 cases non effective, and efficacy rate was 46%. 6. Bacteriologically, disappearance rate of Pseudomonas aeruginosa was 54%(7 out of 13 strains) with 4 strains of vanishment, 6 strains of persistence, and 3 strains of cross over. The cross over bacteria were consisted of Serratia 1 strain, Enterobacter 1 strain and Enterobacter cloacae 1 strain. 7. Adverse reaction was not observed in any case. 8. The efficiacy of CFS against Pseudomonas aeruginosa in the patients with complicated urinary tract infection was confirmed, however, the appearance of micbisme selectionne et substitue should be carefully obseved.