CLINICAL EVALUATION OF PIVMECILLINAM IN ACUTE SIMPLE CYSTITIS A COMPARATIVE STUDY WITH AMOXICILLIN BY A RANDOMIZED DOUBLE-BLIND TECHNIQUE

• Published in: CHEMOTHERAPY Vol. 25; no. 1; pp. 323 - 338
• Main Authors: ISHIGAMI, JOJI, MITA, TOSHIHIKO, TANIKAZE, SABURO, MIYAZAKI, SHIGERU, ONO, SHUTA, KAJINO, KOZO, KANEDA, KUNIHIRO, OHNISHI, MASANAO, AKITA, YASUTOSHI, KURODA, MAMORU, HIROOKA, KYUBEI, KURODA, KIYOTERU, HINENO, TAKASHI, SUEMITSU, HIROSHI, TOMIOKA, SUSUMU, OHNO, SANTARO, HARA, SHINJI, TERASOMA, KAZUNORI, TANAKA, KUNIHIKO, HIKOSAKA, KOJI, SAITO, HIROSHI, HAYASHI, NORINOBU, MORIWAKI, HIROSHI, KOBAYASHI, MINORU, KATAOKA, NOBUMASA, UGA, SHOJI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1977
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.25.323

In order to make clear the usefulness of pivmecillinam (if pivmecillinam is a valuable addition to the existing chemotherepeutic agents), a double-blind controlled study was carried out in acute simple cystitis on pivmecillinam and amoxicillin. The results of this comparative study were as follows : 1. Although the dosage of pivmecillinam was 1/5 that of amoxicillin, the global judgement and the judgement by the urologist in charge significantly favored pivmecillinam over amoxicillin. Especially, a greater number of excellent responses were obtained with pivmecillinam. 2. In judgement of usefulness, pivmecillinam was significantly superior to amoxicillin. 3. When judgen by symptoms, pivmecillinam was significantly superior to amoxicillin in improvement ofbacterial count and urinary frequency. 4. Pivmecillinam was effective for the infection due to amoxicillin-resistant E. coli. 5. Determination of MICs of the causative organisms before and after treatment revealed less development of resistance with pivmecillinam than amoxicillin. 6. Adverse reactions noted were less frequent with pivmecillinam than amoxicillin and no eruption was recognized with pivmecillinam. The results indicate that pivmecillinam is more useful for therapy of acute simple cystitis than amoxicillin.