Therapeutic effect of T-1982 (cefbuperazone) on the gynecologic infectious diseases

• Published in: Japanese journal of antibiotics Vol. 36; no. 5; p. 994
• Main Authors: Kuwabara, S, Tomoda, A, Sugiura, K, Tomita, T, Kato, A, Kanai, H, Kobayashi, H, Yabuki, Y, Asamoto, A, Kato, T
• Format: Journal Article
• Language: Japanese
• Published: Japan 01-05-1983
• Subjects: Adult; Aged; Cephamycins - therapeutic use; Endometritis - drug therapy; Female; Humans; Middle Aged; Pelvic Inflammatory Disease - drug therapy; Peritonitis - drug therapy; Vulvitis - drug therapy
• ISSN: 0368-2781
• DOI: 10.11553/antibiotics1968b.36.994

T-1982 (cefbuperazone), a new cephamycin antibiotic with broad spectrum against Gram-positive, negative aerobic and anaerobic organisms, was clinically and bacteriologically evaluated on the gynecologic infectious diseases. Fourteen cases hospitalized at Kanazawa Medical University Hospital and the affiliated hospitals from October 1981 to July 1982 were treated with T-1982. By clinical symptoms, signs and bacteriological examinations the patients were diagnosed as pelveoperitonitis (1), intrauterine infection (3), adnexitis (3), infectious diseases of external genitalia (4), infectious abortion (1), vulvar hematoma (1), and rectovaginal fistula (1). T-1982 was administered intravenously or by drip infusion at a dose of 0.5-2.0 g twice a day after dissolved in a saline solution or a 5% glucose solution. Based on the improvement of clinical findings and antibacterial effect of T-1982, results were evaluated as excellent, good, poor and unknown. Clinical effects more than good were shown in 9 of 11 cases which could be followed up exactly on the therapeutic of T-1982. Two cases showing poor response were pelveoperitonitis and pyometra under carcinoma colli uteri stage IIIb, respectively. In 8 of 11 cases, antibacterial effect of T-1982 could be evaluated. Thirteen strains of aerobic and anaerobic bacteria were disappeared by T-1982 therapy, while no effect was seen on 5 strains. On the side effect of T-1982, exanthema was observed in 1 case but disappeared soon after the cessation of administration.