Antimycobacterial activity of N1-{1-[3-aryl-1-(pyridin-2-, 3- or 4-yl)-3-oxo] propyl}-2-pyridinecarboxamidrazones

• Published in: Journal of antimicrobial chemotherapy Vol. 48; no. 5; pp. 705 - 707
• Main Authors: Banfi, E., Mamolo, M. G., Zampieri, D., Vio, L., Bragadin, C. Monti
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-11-2001; Oxford Publishing Limited (England)
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Medical sciences; Pharmacology. Drug treatments; Drug susceptibility test; Mycobacterium avium; In vitro; Biological activity; Amidrazone; Pyridine derivatives; Antibiotic; Structure activity relation; Mycobacteriales; Minimum inhibitory concentration; Mycobacteriaceae; Bacteria; Actinomycetes; Antibacterial agent
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/48.5.705

Infections caused by non-tuberculous mycobacteria and multidrug-resistant Mycobacterium tuberculosis are difficult to treat, and so new compounds potentially active against these bacteria are being sought. A series of 2-pyridinecarboxamidrazone derivatives, recently synthesized, have been evaluated for their inhibitory activity against 17 Mycobacterium avium isolates; the agar dilution method showed different degrees of susceptibility to the new molecules. Four molecules, three of which are chlorine derivatives, inhibited 94% of the strains tested with an MIC of 32 mg/L. These data indicate that these new pyridine-2-carboxamidrazones merit further study as antimycobacterial agents.