C005: Pressure response to isometric exercise in young normotensive subjects: Influence of the intracellular potassium

• Published in: American journal of hypertension Vol. 13; no. S2; p. 157A
• Main Authors: Delgado, C.L., Delgado, A., Delgado-León, C.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01-04-2000
• Subjects: intracellular potassium; isometric exercise; physical stress; Potassium
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(00)00653-1

Ki Isometric Exercise (IE), as a physical Stress, may reveal cardiovascular abnormalities not present in at rest. Several studies have reported that young normotensive offspring of hypertensive patients presents abnormal hemodinamic responses during IE. Intracellular Potassium () plays an important role in the pathophysiology of Arterial Hypertension (AH) and its has been proposed as an Intermediate Phenotype. The aim of the study was to evaluate the effect of Ki (mEq/l) in the pressure response during IE. 39 subjects participated in the study (Female n = 20, Male n = 19), age 21.66 ± 2.64 yr., BMI 23.91 ± 2.85 Kg/mt2. Screening for Family History for AH (FH) and physical examination was performed. Blood sample for red blood cell Ki was taken at basal conditions. Pulse and Blood pressure (SBP, DBP, MBP) were obtained at basal and during IE. Later patients and data were grouped according to Ki (Ki 88 mEq/L is considered as lower threshold) and FH: (1) Ki < 88/FH(+), (2) Ki < 88/FH(−), (3) Ki ≥ 88/FH(+) y (4) Ki ≥ 88/FH(−). At basal conditions, a progressive increase of Ki, from group (1) to (4) was observed. ANOVA test showed statistical difference in Ki (F = 17.870, p < 0.0001) and MBP (F = 14.63, p < 0.0001) within the 4 groups; not quite statistical significance in DBP (F = 2.645, p = 0.069). Statistical difference was obtained in DBP (p = 0.046) and MBP (p = 0.042) only when (1) vs (4) groups were compared. Besides, a tendency of decrease of blood pressure and pulse with progressive increase of Ki, was also observed. During IE, ANOVA showed statistical difference in DBP (F = 3.693, p = 0.020) and MBP (F = 3.341, p = 0.030). Statistical difference was observed in DBP and MBP when compare (1) vs (4): (DBP p = 0.020 y MBP p = 0.035) y (K3) vs (4): (DBP p = 0.006 y MBP p = 0.0419). When comparing data at basal and during IE, statistical difference was found in groups (1) and (2). Pulse shows no difference in group (3). No statistical difference was observed in group (4). Ki, together with FH, influence the pressure response at IE in young normotensive subjects.