Detection of focal epileptiform activity in the EEG: an SVD and dipole model approach

• Published in: Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology Vol. 3; pp. 2031 - 2032 vol.3
• Main Authors: Vanrumste, B., Jones, R.D., Bones, P.J.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 2002
• Subjects: Biomedical engineering; Bones; Brain modeling; Detection algorithms; Electroencephalography; Epilepsy; Hospitals; Physics; Singular value decomposition; Synchronous generators
• ISBN: 0780376129; 9780780376120
• ISSN: 1094-687X; 1558-4615
• DOI: 10.1109/IEMBS.2002.1053152

An algorithm has been developed for detection of epileptiform activity in the EEG. The EEG is divided into overlapping epochs, which undergo two steps. The first is singular value decomposition (SVD) which identifies the number of uncorrelated active sources in an epoch. In the second step, EEG dipole source analysis, using a single dipole model, is applied to the EEG. This yields dipole parameters and a relative residual energy (RRE). The detection algorithm triggers an EEG epoch when SVD indicates a dominant source and the RRE is low. The algorithm is applied to simulated EEG generated by two sources which are synchronously and asynchronously active. For the synchronous case the critical measure is the RRE whereas for the asynchronous case both the SVD and RRE are critical. The algorithm has also been applied to real EEG containing two spikes and an eye-blink artifact. The SVD indicated a dominant active source and the RRE was low for all three events. These preliminary results demonstrate the potential of the method for detection of spikes and seizures with a focal origin.