Implementation of Genetic Algorithm-Support Vector Machine on Gene Expression Data in Identification of Non-Small Cell Lung Cancer in Nonsmoking Female

• Published in: 2022 5th International Conference of Computer and Informatics Engineering (IC2IE) pp. 361 - 366
• Main Authors: Ramadhani Rohimat, Tasya Nurfauziah, Nhita, Fhira, Kurniawan, Isman
• Format: Conference Proceeding
• Language: English
• Published: IEEE 13-09-2022
• Subjects: Computational modeling; Feature extraction; genetic algorithm; Lung cancer; microarray; non-small cell lung cancer (NSCLC); Prediction algorithms; Predictive models; RNA; Support vector machine classification; support vector machines
• DOI: 10.1109/IC2IE56416.2022.9970077

Lung cancer is the leading cause of death in the world. There are two types of lung cancer, i.e., non-small cell lung cancer and small cell lung cancer. The major cause of lung cancer is smoking. However, there are several cases of non-small lung cancer, with 7% of women with lung cancer in Taiwan having a smoking history. Early detection of cancer will help it go faster and save lives every year. Nowadays, the technology being used is very helpful in the medical field because it uses microarray technology which can help detect cancer in the early phase by analyzing DNA and RNA. In this study, we utilized GA combined with SVM for the classification of Non-Small Cell Lung Cancer in a non-smoking female with microarray data. Hyperparameter tuning is performed to improve model performance. We discovered that SVM with a linear kernel performs better than alternative kernels with accuracy and F1-score values of 0.91 and 0.91, respectively.