A comparative study of 4 Fr versus 6 Fr nasobiliary drainage catheters: A randomized, controlled trial

• Published in: Journal of gastroenterology and hepatology Vol. 29; no. 3; pp. 653 - 659
• Main Authors: Ishigaki, Takashi, Sasaki, Tamito, Serikawa, Masahiro, Minami, Tomoyuki, Okazaki, Akihito, Yukutake, Masanobu, Ishii, Yasutaka, Kosaka, Keiichi, Mouri, Teruo, Yoshimi, Satoshi, Chayama, Kazuaki
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01-03-2014
• Subjects: Aged; Aged, 80 and over; Bile - secretion; Bilirubin - metabolism; Catheters; Cholangiopancreatography, Endoscopic Retrograde - adverse effects; Cholangiopancreatography, Endoscopic Retrograde - instrumentation; Drainage - adverse effects; Drainage - instrumentation; endoscopic retrograde cholangiopancreatography; Female; Humans; Jaundice, Obstructive - metabolism; Jaundice, Obstructive - physiopathology; Jaundice, Obstructive - therapy; Male; Middle Aged; Pancreatitis - epidemiology; Pancreatitis - etiology; Pancreatitis - prevention & control; post-endoscopic retrograde cholangiopancreatography pancreatitis; Prevalence; Prospective Studies; Treatment Outcome; visual analog scale; endoscopic retrograde cholangiopancreatography; visual analog scale; post-endoscopic retrograde cholangiopancreatography pancreatitis
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.12427

Background and Aim
Despite the benefits of endoscopic nasobiliary drainage (NBD) in endoscopic retrograde cholangiopancreatography (ERCP), post‐ERCP pancreatitis (PEP) and nose/throat discomfort can result. We aimed to determine whether the use of a smaller catheter alleviates these complications.
Method
A randomized, controlled trial at a tertiary care center compared 4 Fr and 6 Fr NBD catheters; 165 ERCP patients with naïve papillae were randomly assigned to a catheter‐size group.
Results
The prevalence of PEP was significantly lower in the 4 Fr group (3.7%; 3/82) than in the 6 Fr group (15.7%; 13/83; P = 0.019). No spontaneous catheter displacement occurred within 24 h. Discomfort visual analog scores were 2.6 and 4.3 in the 4 Fr and 6 Fr groups, respectively (P = 0.0048) on procedure day; on the following day, the scores were 2.3 and 3.6 (P = 0.028). Bile output was 16.3 mL/h and 21.4 mL/h in the 4 Fr and 6 Fr groups (P = 0.051). On obstructive jaundice subgroup analysis, bile drainage was 19.2 mL/h and 22.1 mL/h in the 4 Fr and 6 Fr groups (P = 0.40). The 4 Fr group required 5.6 days to reduce bilirubin levels versus 6.1 days in the 6 Fr group (P = 0.51).
Conclusions
In patients with naïve papillae, lower rates of PEP and less nose/throat discomfort are associated with the use of 4 Fr NBD catheters. In patients with obstructive jaundice, 4 Fr and 6 Fr catheters are comparable with regard to bile output and bilirubin level reduction.