Vitamin D-receptor polymorphisms and non-tuberculous mycobacterial lung disease in Korean patients [Short Communication]

• Published in: The international journal of tuberculosis and lung disease Vol. 12; no. 6; pp. 698 - 700
• Main Authors: PARK, S, KIM, E. J, LEE, S.-H, SUH, G. Y, CHUNG, M. P, KIM, H, KWON, O. J, KOH, W-J
• Format: Journal Article
• Language: English
• Published: Paris, France IUATLD 01-06-2008; Union internationale contre la tuberculose et les maladies respiratoires
• Subjects: Adult; Asian Continental Ancestry Group - genetics; Atypical Mycobacteria; Biological and medical sciences; Female; Genetic Predisposition To Disease; Genetic Predisposition to Disease - ethnology; Humans; Korea; Lung Disease; Lung Diseases - ethnology; Lung Diseases - genetics; Lung Diseases - microbiology; Male; Medical sciences; Miscellaneous; Mycobacterium; Mycobacterium avium-intracellulare Infection - genetics; Mycobacterium Infections - genetics; Pneumology; Point Mutation; Polymorphism, Single Nucleotide; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Receptors, Calcitriol - genetics; Vitamin D; Asia; Korea; Human; Mycobacterium; Lung disease; Respiratory disease; Vitamin D receptor; Mycobacterial infection; Genetic determinism; Infection; atypical mycobacteria; Vitamin D; Mycobacteriales; Point mutation; Predisposition; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes; Atypical; genetic predisposition to disease; Pneumology; Polymorphism
• ISSN: 1027-3719; 1815-7920

This study investigated the potential role of vitamin D-receptor (VDR) gene polymorphisms in susceptibility to lung disease caused by non-tuberculous mycobacteria (NTM). TaqI and FokI polymorphisms were compared in 124 patients and 127 controls. The genotype, allele and
haplotype frequencies did not differ between patients and controls. TaqI and FokI polymorphisms of the VDR gene do not appear to be responsible for host susceptibility to NTM lung disease, at least in this Korean population. An association cannot, however, be completely ruled
out, as only two single nucleotide polymorphisms of the VDR gene were studied in this report.