Synthesis and pharmacological evaluation of novel potential ultrashort-acting beta-blockers

The basic relationship between chemical structure and pharmacological activity of eight newly developed potential ultrashort-acting beta-adrenergic blockers was evaluated. The compounds studied are derivatives of arylcarbonyloxyaminopropanols and were prepared by four-step synthesis. All the compoun...

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Bibliographic Details
Published in:	Pharmazie Vol. 58; no. 1; p. 18
Main Authors:	Mokrý, P, Zemanová, M, Csöllei, J, Racanská, E, Tumová, I
Format:	Journal Article
Language:	English
Published:	Germany 01-01-2003
Subjects:	Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - chemical synthesis Adrenergic beta-Antagonists - pharmacology Animals Anti-Arrhythmia Agents - chemical synthesis Anti-Arrhythmia Agents - pharmacology Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - prevention & control Guinea Pigs Heart Rate - drug effects In Vitro Techniques Isoproterenol - antagonists & inhibitors Isoproterenol - pharmacology Magnetic Resonance Spectroscopy Muscle Contraction - drug effects Muscle, Smooth - drug effects Myocardial Contraction - drug effects Ouabain - antagonists & inhibitors Ouabain - toxicity Propanolamines - chemical synthesis Propanolamines - pharmacology Spectrophotometry, Infrared Spectroscopy, Fourier Transform Infrared Trachea - drug effects
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Summary:	The basic relationship between chemical structure and pharmacological activity of eight newly developed potential ultrashort-acting beta-adrenergic blockers was evaluated. The compounds studied are derivatives of arylcarbonyloxyaminopropanols and were prepared by four-step synthesis. All the compounds evaluated showed weak antiisoprenaline (beta-adrenergic receptor blocking) activity and antiarrhythmic (antiouabain) activity.
ISSN:	0031-7144