Atypical radiological images of pulmonary tuberculosis in 192 diabetic patients: a comparative study

• Published in: The international journal of tuberculosis and lung disease Vol. 5; no. 5; pp. 455 - 461
• Main Authors: Pérez-Guzman, C, Torres-Cruz, A, Villarreal-Velarde, H, Salazar-Lezama, M A, Vargas, M H
• Format: Journal Article
• Language: English
• Published: Paris The International Union Against Tuberculosis & Lung Disease 01-05-2001; Union internationale contre la tuberculose et les maladies respiratoires
• Subjects: Adult; Age Distribution; Bacterial diseases; Biological and medical sciences; Cavitation; Chest X-Rays; Comparative Study; Diabetes Complications; Diabetes Mellitus; Female; Human bacterial diseases; Humans; Infectious diseases; Leukocyte Count; Logistic Models; Lung - pathology; Male; Medical sciences; Mexico - epidemiology; Middle Aged; Pulmonary Tuberculosis; Radiography; Radiology; Retrospective Studies; Roentgenogram; Sex Distribution; Statistics, Nonparametric; Tropical medicine; Tuberculosis and atypical mycobacterial infections; Tuberculosis, Pulmonary - diagnostic imaging; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - pathology; Endocrinopathy; Human; Lung disease; Radiodiagnosis; Pathophysiology; Respiratory disease; Diabetes mellitus; Exploration; Mycobacterial infection; Bronchopulmonary; Infection; Radiography; Concomitant disease; Tuberculosis; Bacteriosis; Bronchus disease; Diagnosis; Comparative study
• ISSN: 1027-3719; 1815-7920

SETTING: Comparative studies of pulmonary tuberculosis images in diabetics have yielded conflicting results.OBJECTIVE: To assess radiological images of pulmonary tuberculosis in a large population of diabetic patientsDESIGN: Radiographs from in-patients admitted with pulmonary tuberculosis and diabetes (TBDM group, n = 192) were reviewed and compared with a control group of patients with pulmonary tuberculosis alone (TB group, n = 130).RESULTS: Both groups had a similar evolution time of tuberculosis (∼2 years). Statistical differences were observed as follows: TBDM patients were older (51.3 ± 0.9 vs. TB group 44.9 ± 1.8 years, mean ± SEM), and had a decreased frequency of upper (17% vs. 56%), and an increased frequency of lower (19% vs. 7%) and upper + lower (64% vs. 36%) lung field lesions. More TBDM patients developed cavitations (82% vs. 59%) more often in the lower lung fields (29% vs. 3%). More multiple cavities were seen in TBDM patients (25% vs. 2%). TBDM group had a lower total leukocyte count (8836.7 ± 219.5 vs. 10013.1 ± 345.2 cells/mm3), mainly due to a lower number of non-lymphocyte cells (6815.8 ± 221.8 vs. 8095.7 ± 321.9 cells/mm3). Multiple logistic regression showed that being a diabetic patient was the most important factor determining lower lung field lesions and cavities.CONCLUSIONS: This study in a large number of diabetics with pulmonary tuberculosis confirmed that their chest X-ray images significantly depart from the typical presentation. Clinicians must keep this in mind to avoid misdiagnosis.