Influenza Vaccination and Theophylline Pharmacokinetics in Patients With Chronic Obstructive Lung Disease

Total Theophylline clearance rate was measured before and 24 hours after standard influenza vaccination in seven men with stable chronic obstructive lung disease. In four, total theophylline clearance rate was also measured 48 hours after vaccine administration. There was no significant change in th...

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Bibliographic Details
Published in:	The Western journal of medicine Vol. 139; no. 5; pp. 651 - 654
Main Authors:	Stults, Barry M., Hashisaki, Peter A.
Format:	Journal Article
Language:	English
Published:	United States BMJ Publishing Group LTD 01-11-1983
Subjects:	Aged Clinical Investigation Humans Influenza Vaccines - adverse effects influenza virus Kinetics Lung Diseases, Obstructive - metabolism Male Metabolic Clearance Rate Middle Aged Theophylline - metabolism Time Factors
Online Access:	Get full text
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Summary:	Total Theophylline clearance rate was measured before and 24 hours after standard influenza vaccination in seven men with stable chronic obstructive lung disease. In four, total theophylline clearance rate was also measured 48 hours after vaccine administration. There was no significant change in the clearance rate after either time interval. These results do not support recent recommendations to monitor serum theophylline concentrations or reduce theophylline dosage during the 48-hour period following influenza vaccination. Nevertheless, pending further studies, patients maintained on a regimen of theophylline preparations should be followed clinically for theophylline toxicity for the first several days after receiving influenza vaccine.
Bibliography:	istex:0FF46DE14D93F13F314AF1A399BECDF302958A05 PMID:6659488 ark:/67375/NVC-1TSQ8288-M ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0093-0415 1476-2978