Fluoroform-Derived CuCF3 for Low-Cost, Simple, Efficient, and Safe Trifluoromethylation of Aryl Boronic Acids in Air

Fluoroform-Derived CuCF3 for Low-Cost, Simple, Efficient, and Safe Trifluoromethylation of Aryl Boronic Acids in Air

Easy does it: Aryl boronic acids undergo smooth and selective trifluoromethylation with low‐cost fluoroform‐derived CuCF3 in DMF in non‐dried air. The reaction occurs under mild conditions (1 atm, room temperature), exhibits unprecedented functional‐group tolerance, and affords trifluoromethylated a...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 51; no. 31; pp. 7767 - 7770
Main Authors: Novák, Petr, Lishchynskyi, Anton, Grushin, Vladimir V.
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 27-07-2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Edition:International ed. in English
Subjects:
Air
arenes
aryl boronic acids
Boronic Acids - chemistry
copper
fluorine
Hydrocarbons, Fluorinated - chemical synthesis
Hydrocarbons, Fluorinated - chemistry
Molecular Structure
Organometallic Compounds - chemistry
Stereoisomerism
trifluoromethylation
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Summary:Easy does it: Aryl boronic acids undergo smooth and selective trifluoromethylation with low‐cost fluoroform‐derived CuCF3 in DMF in non‐dried air. The reaction occurs under mild conditions (1 atm, room temperature), exhibits unprecedented functional‐group tolerance, and affords trifluoromethylated aromatic compounds in up to 99 % yield.
Bibliography:ark:/67375/WNG-2J7VR3R9-3
ArticleID:ANIE201201613
istex:7E48EC5870738EDDEE22B31F4D20E3024970CE47
Consolider Ingenio 2010 - No. CSD2006-0003
The Spanish Government - No. CTQ2011-25418
The ICIQ Foundation, Consolider Ingenio 2010 (Grant CSD2006-0003), and The Spanish Government (Grant CTQ2011-25418) are thankfully acknowledged for support of this research.
ICIQ Foundation
The ICIQ Foundation, Consolider Ingenio 2010 (Grant CSD2006‐0003), and The Spanish Government (Grant CTQ2011‐25418) are thankfully acknowledged for support of this research.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201201613