Experimental evaluation of stem bark of Stryphnodendron adstringens (Mart.) Coville for antiinflammatory activity

• Published in: Phytotherapy research Vol. 12; no. 3; pp. 218 - 220
• Main Authors: Lima, J. C. S., Martins, D. T. O., de Souza Jr, P. T.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-05-1998; Wiley
• Subjects: acetone soluble fraction; antiinflammatory action; bark extract; Biological and medical sciences; General pharmacology; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Stryphnodendron adstringens; South America; Brazil; America; Rat; Pharmacognosy; Rodentia; Antiinflammatory agent; Bark; Biological activity; Medicinal plant; Vertebrata; Mammalia; Leguminosae; Folk medicine; Mouse; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/(SICI)1099-1573(199805)12:3<218::AID-PTR220>3.0.CO;2-4

The acetone soluble fraction from the crude extract of Stryphnodendron adstringens stem bark was evaluated in acute and chronic models of inflammation. It was found to cause significant inhibition of rat paw oedema induced by carrageenan and dextran; the exudate volume and migration of leukocyte number in the rat pleurisy test and also in the hind paw swelling in rats on Freund's adjuvant‐induced arthritis. In addition, it significantly decreased the vascular permeability increase caused by intraperitoneal acetic acid in mice. These findings support the traditional use of S. adstringens bark extracts in the treatment of inflammatory conditions. © 1998 John Wiley & Sons, Ltd.