Soft-tissue necrosis induced by extravasated cancer chemotherapeutic agents

The inadvertent extravasation of anticancer drugs in clinical use may result in the development of indolent lesions at the site of injection. Investigation of this phenomenon in Hartley guinea pigs showed that the pathogenesis was based on direct tissue toxicity and not on sensitization. The risk of...

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Bibliographic Details
Published in:	JNCI : Journal of the National Cancer Institute Vol. 66; no. 6; p. 1129
Main Authors:	Barr, R D, Benton, S G, Belbeck, L W
Format:	Journal Article
Language:	English
Published:	United States 01-06-1981
Subjects:	Animals Antineoplastic Agents - adverse effects Guinea Pigs Injections, Intradermal - adverse effects Injections, Subcutaneous Necrosis - chemically induced Skin - drug effects Skin - pathology
Online Access:	Get more information
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Summary:	The inadvertent extravasation of anticancer drugs in clinical use may result in the development of indolent lesions at the site of injection. Investigation of this phenomenon in Hartley guinea pigs showed that the pathogenesis was based on direct tissue toxicity and not on sensitization. The risk of a serious reaction appeared to be related to the localization of the injurious agent within the dermis rather than at the subcutaneous site.
ISSN:	0027-8874
DOI:	10.1093/jnci/66.6.1129