Efficiency of Fe3O4@ZIF-8 for the removal of Doxorubicin from aqueous solutions: equilibrium, kinetics and thermodynamic studies

• Published in: Environmental technology Vol. 45; no. 4; pp. 731 - 750
• Main Authors: A. A. Al-Hazmi, Gamil, El-Zahhar, Adel A., El-Desouky, Mohamed G., El-Bindary, Mohamed A., El-Bindary, Ashraf A.
• Format: Journal Article
• Language: English
• Published: Abingdon Taylor & Francis 2024; Taylor & Francis Ltd
• Subjects: Adsorption; anti-COVID-19; Anticancer; Anticancer properties; Antitumor agents; Aquatic environment; Aquatic organisms; Aqueous solutions; Cancer; Contaminants; COVID-19; Doxorubicin; Iron oxides; Medical wastes; Molecular docking; Nanocomposites; Pharmaceutical industry; Pharmaceutical industry wastes; Pharmaceuticals; Physical characteristics; Physical properties; Pollution abatement; Pollution prevention; Prostate cancer; Shaking; Thermodynamic equilibrium; Thermodynamic properties; Thermodynamics; Wastewater treatment; Williamson-Hall (W-H) method; Zeta potential
• ISSN: 0959-3330; 1479-487X
• DOI: 10.1080/09593330.2022.2121181

Due to inadequate pharmaceutical wastewater treatment, anticancer contaminants from the pharmaceutical industry frequently end up in the aquatic environment where they endanger aquatic life and humans. As a result, the appropriate treatment of wastewater that contains anticancer agents is crucial for pollution prevention. The purpose of this work is to assess the effectiveness of a Fe
3
O
4
@ZIF-8 nanocomposite as an adsorbent to remove of the chemotherapeutic drugs doxorubicin (DOX) from aqueous solution. SEM, XRD, BET, FT-IR, Zeta potential, and point of zero charge analysis were used to study the surface and structural characteristics of the Fe
3
O
4
@ZIF-8 nanocomposite. Via the proposed treatment, 804.84 mg/g elimination was successful under the following circumstances: pH = 6; Fe
3
O
4
@ZIF-8 dose = 0.02 g/25 mL; DOX concentration = 1.22x10
−3
 mol; adsorption time = 100 min; and shaking speed = 200 rpm. A investigation of isotherms shown that the Langmuir equation and experimental data suited each other quite well. The adsorption of DOX on Fe
3
O
4
@ZIF-8 was endothermic and spontaneous, in accordance with thermodynamic properties. Furthermore, the elimination of DOX was enhanced by the rise in solution temperature. The kinetic analysis revealed that the pseudo-second order was fitted by the model. The suggested adsorption method could recycle Fe
3
O
4
@ZIF-8 nanocomposite six times, with a modest reduction in its ability for adsorption. For all XRD reflection peaks, physical characteristics including strain rates were computed and the dislocation of was 4.7 × 10
−6
. Investigate the activity of the DOX towards COVID-19, breast and prostate cancer using molecular docking.