Synthesis of 3-amino-5H-pyrimido[5,4-b]indol-4-one derivatives

• Published in: Journal of heterocyclic chemistry Vol. 24; no. 2; pp. 437 - 439
• Main Authors: Monge, A., Palop, J. A., Parrado, P., Perez-Ilzarbe, C., Fernández-Alvarez, E.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley-Blackwell 01-03-1987; Wiley‐Blackwell; HeteroCorporation
• Subjects: Chemistry; Exact sciences and technology; Heterocyclic compounds; Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings; Organic chemistry; Preparations and properties; Organic hydrazide; Nitrogen heterocycle; Semicarbazides; Aromatic compound; Tricyclic compound; Biological activity; Antiplatelet agent
• ISSN: 0022-152X; 1943-5193
• DOI: 10.1002/jhet.5570240226

Starting with ethyl 3‐aminoindole‐2‐carboxylate, the synthesis of 3‐amino‐5H‐pyrimido[5,4‐b]indole‐2,4‐dione 5, 3‐amino‐5H‐pyrimido[5,4‐b]indol‐4‐one 10 and some related compounds is described. Preliminary results about the inhibition of platelet aggregation by these compounds is reported.