Synthesis of 4-aroyl-5-nitro-1H-imidazoles and 4-aroyl-5-aminoimidazoles

The reaction of α‐(aryl)‐4‐morpholineacetonitriles (masked aroyl anion equivalents) with N‐protected 4(5)‐bromo‐5(4)‐nitro‐1H‐imidazoles gave 4‐aroyl‐5‐nitroimidazoles which were reduced to afford 4‐aroyl‐5‐aminoimidazoles.

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Bibliographic Details
Published in:	Journal of heterocyclic chemistry Vol. 23; no. 3; pp. 913 - 919
Main Authors:	Albright, J. Donald, Moran, Daniel B.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley-Blackwell 01-05-1986 Wiley‐Blackwell HeteroCorporation
Subjects:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry Preparations and properties Benzenic compound Five membered ring NMR spectrum Nitrogen heterocycle Ketone
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Description
Summary:	The reaction of α‐(aryl)‐4‐morpholineacetonitriles (masked aroyl anion equivalents) with N‐protected 4(5)‐bromo‐5(4)‐nitro‐1H‐imidazoles gave 4‐aroyl‐5‐nitroimidazoles which were reduced to afford 4‐aroyl‐5‐aminoimidazoles.
Bibliography:	istex:D879EF870726B587A45324068B9F4BA385882341 ark:/67375/WNG-200SGS97-7 ArticleID:JHET5570230350
ISSN:	0022-152X 1943-5193
DOI:	10.1002/jhet.5570230350