Robustness of Beta Desynchronization from Chronically Implanted Cortical Electrodes on Multiple Time Scales

• Published in: 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) Vol. 2021; pp. 6041 - 6044
• Main Authors: Fraczek, Tomasz M., Ko, Andrew L., Chizeck, Howard J., Herron, Jeffrey A.
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States IEEE 01-11-2021
• Subjects: Biology; Deep Brain Stimulation; Electrodes; Essential Tremor - therapy; Humans; Parkinson Disease - therapy; Reproducibility of Results; Robustness; Strips
• ISSN: 2694-0604
• DOI: 10.1109/EMBC46164.2021.9629927

Adaptive deep brain stimulation (aDBS) promises a significant improvement in patient outcomes, compared to existing deep brain stimulation devices. Fully implanted systems represent the next step to the clinical adoption of aDBS. We take advantage of a unique longitudinal data set formed as part of an effort to investigate aDBS for essential tremor to verify the long term reliability of electrocorticography strips over the motor cortex as a source of bio-markers for control of adaptive stimulation. We show that beta band event related de-synchronization, a promising bio-marker for movement, is robust even when used to trigger aDBS. Over the course of several months we show a minor increase in beta band event related de-synchronization in patients with active deep brain stimulation confirming that it could be used in chronically implanted systems.Clinical relevance - We show the promise and practicality of cortical electrocorticography strips for use in fully implanted, clinically translatable, aDBS systems.