Genomic Signature of Membrane Permeation Induced by Intense THz Pulses

Genomic Signature of Membrane Permeation Induced by Intense THz Pulses

Intense THz pulses have been shown to induce non-thermal biological effects at multiple scales of structural organization, including differential gene expressions in human skin tissue. Epidermal differentiation is a calcium-regulated process, and an excellent candidate for studying genetics of THz-i...

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Bibliographic Details
Published in:2020 45th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) pp. 1 - 2
Main Authors: Hough, Cameron M., Purschke, David N., Huang, Chenxi, Titova, Lyubov V., Kovalchuk, Olga, Warkentin, Brad J., Hegmann, Frank A.
Format: Conference Proceeding
Language:English
Published: IEEE 08-11-2020
Subjects:
Biomembranes
Epidermis
Fluorescence
Gene expression
Genomics
Organizations
Permeability
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Summary:Intense THz pulses have been shown to induce non-thermal biological effects at multiple scales of structural organization, including differential gene expressions in human skin tissue. Epidermal differentiation is a calcium-regulated process, and an excellent candidate for studying genetics of THz-induced biological effects due to the strong over-representation of THz-affected genes in these processes. Results indicate application of THz for targeted inhibition of mitotic activity in skin, and additionally suggest membrane permeation as a key mechanism of THz-induced biological effects. Preliminary experiments investigating fluorescence detection of membrane permeability and techniques of field enhancement in THz-exposed cell lines will be discussed.
ISSN:2162-2035
DOI:10.1109/IRMMW-THz46771.2020.9370436