Retarded growth of lymphoma in immunodepressed mice

Lymphoma cells were inoculated iv into normal and immunodepressed mice. In most instances the immunodepressed animals survived longer than their normal counterparts. This was true both with athymic and thymectomized animals that had been lethally irradiated and reconstituted with syngeneic bone marr...

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Bibliographic Details
Published in:	JNCI : Journal of the National Cancer Institute Vol. 58; no. 4; p. 1131
Main Authors:	Gillette, R W, Wunderlich, D A
Format:	Journal Article
Language:	English
Published:	United States 01-04-1977
Subjects:	Animals Immunosuppression Lymphoma - immunology Lymphoma - pathology Mice Mice, Inbred A Mice, Inbred BALB C Mice, Nude Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology
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Summary:	Lymphoma cells were inoculated iv into normal and immunodepressed mice. In most instances the immunodepressed animals survived longer than their normal counterparts. This was true both with athymic and thymectomized animals that had been lethally irradiated and reconstituted with syngeneic bone marrow. The route of administration was critical, since increased survival of immunodeficient animals was not observed when the lymphoma cells were injected ip.
ISSN:	0027-8874
DOI:	10.1093/jnci/58.4.1131