Numerical simulation of transient response of chemical and biological micro/nanofabricated sensors operating in multianalyte environments

• Published in: 2014 29th International Conference on Microelectronics Proceedings - MIEL 2014 pp. 187 - 190
• Main Authors: Radulovic, K. T., Jokic, I. M., Frantlovic, M. P., Djuric, Z. G.
• Format: Conference Proceeding
• Language: English
• Published: IEEE 01-05-2014
• Subjects: Adsorption; Analytical models; Approximation methods; Equations; Mathematical model; Sensors; Surface treatment
• ISBN: 1479952958; 9781479952953
• DOI: 10.1109/MIEL.2014.6842117

In different kinds of surface-based chemical and biological micro/nanosensors, interpretation of the experimentally obtained data is performed based on approximate solutions for the sensor response, valid for the case of single-analyte samples. A question arises whether or not the approximate models used for experimental data fitting in the case of a single analyte are also applicable for multianalyte environments. We test the validity of the two-compartment model for approximation of sensor transient response in the case of concurrent binding of multiple analytes on the sensing surface, by comparing the approximate response with the numerical simulation of the dynamics of a real adsorption experiment.