High contrast reporter cleavage detection for enhancing porous silicon sensor sensitivity

We show the first experimental implementation of biosensing using high contrast reporter cleavage detection (HCRCD). HCRCD makes use of dramatic signal amplification caused by cleavage of high-contrast nanoparticle labeled reporters instead of the capture of low-index bio- molecules.

Saved in:

Bibliographic Details
Published in:	2021 Conference on Lasers and Electro-Optics (CLEO) pp. 1 - 3
Main Authors:	Layouni, Rabeb, Dubrovsky, Michael, Bao, Mengdi, Chung, Haejun, Du, Ke, Boriskina, Svetlana V., Weiss, Sharon M., Vermeulen, Diedrik
Format:	Conference Proceeding
Language:	English
Published:	OSA 01-05-2021
Subjects:	DNA Measurement by laser beam Pathogens Pressure measurement Reflectivity Sensitivity Sensors
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We show the first experimental implementation of biosensing using high contrast reporter cleavage detection (HCRCD). HCRCD makes use of dramatic signal amplification caused by cleavage of high-contrast nanoparticle labeled reporters instead of the capture of low-index bio- molecules.