THE α1b-ADRENERGIC RECEPTOR SUBTYPE: MOLECULAR PROPERTIES AND PHYSIOLOGICAL IMPLICATIONS

THE α1b-ADRENERGIC RECEPTOR SUBTYPE: MOLECULAR PROPERTIES AND PHYSIOLOGICAL IMPLICATIONS

ABSTRACT The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the α1b-adrenergic receptor. Experimental and computational mutagenesis of the α1b-adrenergic receptor have been in...

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Bibliographic Details
Published in:Journal of receptors and signal transduction Vol. 22; no. 1-4; pp. 1 - 16
Main Authors: Cotecchia, Susanna, Björklöf, Katja, Rossier, Olivier, Stanasila, Laura, Greasley, Peter, Fanelli, Francesca
Format: Journal Article
Language:English
Published: Informa UK Ltd 2002
Taylor & Francis
Subjects:
Adrenergic receptor
Online Access:Get full text
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Summary:ABSTRACT The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the α1b-adrenergic receptor. Experimental and computational mutagenesis of the α1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the α1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.
ISSN:1079-9893
1532-4281
DOI:10.1081/RRS-120014585